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Using OxyContin chronically can result oxycontin pills in increased tolerance to the drug in new oxycontin which higher doses of the medication must be taken to receive the initial effect. Over time, OxyContin the new oxycontin will be come physically addictive, causing a person to experience withdrawal new oxycontin pills symptoms when the drug is not present. Symptoms of withdrawal include restlessness, muscle and bone pain, insomnia, diarrhea, vomiting, cold flashes with goose bumps, and involuntary leg movements.The most serious risk associated with OxyContin, is respiratory depression. Because of this, OxyContin should not be combined with other substances that slow down breathing, such as alcohol, antihistamines (like some cold or allergy medication), barbiturates, or benzodiazepines. Other common side effects include constipation, nausea, sedation, dizziness, vomiting, headache, dry mouth, sweating, and weakness. Toxic overdose and/or death can occur by taking the tablet broken, chewed, or crushed. People who abuse the drug (by removing the time-release coating) will experience effects for up to 5 hours. The high that is felt is opiate-like - a sedate, euphoric feeling.